Mechanism of Action

 

  • Bakutrol™ stands as a versatile and potent solution, effectively tackling both acne and Post-Inflammatory Hyperpigmentation (PIH) through its comprehensive approach

  • Initially addressing acne, it then focuses on the reduction of tyrosinase activity, which is crucial in melanin formation, thereby effectively managing the resultant skin darkening associated with PIH

  • This is achieved through its substantial anti-tyrosinase action, coupled with its robust anti-inflammatory, antioxidant, and antibacterial properties

  • Additionally, Bakutrol™ exhibits a potent antioxidant capability, evidenced by its high ORAC 5.0 value, which enables it to quench various free radicals

  • This wide-ranging impact underscores Bakutrol™ as a multifaceted and effective product for simultaneously combating these skin concerns

Key Pointers

 
  • Bakutrol™ is a plant based ingredient containing 0.5% bakuchiol
  • It’s proprietary technology ensures that Bakutrol™ is free from Psoralen & Isopsoralen
  • Psoralen & Isopsoralen are known skin irritants commonly found in some Bakuchiol formulations which increase pigmentation
  • Carefully crafted & has a mild lightweight formula with, easy topical application
  • Promotes clear skin and improves skin tone
  • Human and in vitro safety testing with no adverse effects
  • Safe and well-tolerated
  • Patented cosmetic active

Clinical Findings

 
  • Bakutrol™ is clinically validated in 4 clinical trials to effectively treat acne and PIH
  • Clinically studied in Fitzpatrick skin type 3-6 with no adverse effects
  • 29% reduction in acne-induced PIH in just 4 weeks
  • 58% reduction in inflammatory lesions in 8 weeks
  • Reduces non-inflammatory lesions as well
  • 43% inhibition in tyrosinase expression and 15% reduction in melanin expression
  • Potency of Bakutrol™ at 5 μM was equivalent to a well-known melanogenesis inhibitor, Phenylthiourea (PTU) at 10 μM
  • Indian clinical trial of 50 women

Indication

Acne Post-Inflammatory Hyperpigmentation (PIH)

Dosage Forms

  • Lotion

  • Cream